Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 18, Issue 3, Pages 282-289Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2008.04.003
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R01 GM061909, R01 GM061909-07, R01 GM067777, GM061909, GM067777, R01 GM067777-05] Funding Source: Medline
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The recent two years have led to the realization that histone chaperones contribute to the delicate balance between nucleosome assembly and re-assembly during transcription, and may in fact be involved as much in histone eviction as they are in chromatin assembly. Recent structural studies (in particular, the structure of an Asf1-H3/H4 complex) have suggested mechanisms by which this may be accomplished. The incorporation of various histone variants into nucleosomes has diverse effects on nucleosome structure, stability, and the ability of nucleosomal arrays to condense into chromatin higher order structures. It is likely that these seemingly independent ways to modify chromatin structure are interdependent.
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