Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 18, Issue 5, Pages 593-600Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2008.06.009
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Funding
- National Institute of General Medical Science
- National Institutes of Health [1R01GM071939-01]
- LANL LDRD [20070131ER, 20080001DR]
- Office of Biological and Environmental Research of the Department of Energy
- Human Frontiers Science Program
- National de la Recherche Scientifique (CNRS)
- Institut National de la Sante et de la Recherche Medicale
- Hopital Universitaire de Strasbourg
- MEXT of Japan
- Human Frontiers Science Program [RGP0021/2006-C]
- European Commission [011995 CISB]
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Neutron crystallography has had an important, but relatively small role in structural biology over the years. In this review of recently determined neutron structures, a theme emerges of a field currently expanding beyond its traditional boundaries, to address larger and more complex problems, with smaller samples and shorter data collection times, and employing more sophisticated structure determination and refinement methods. The origin of this transformation can be found in a number of advances including first, the development of neutron image-plates and quasi-Laue methods at nuclear reactor neutron sources and the development of time-of-flight Laue methods and electronic detectors at spallation neutron sources; second, new facilities and methods for sample perdeuteration and crystallization; third, new approaches and computational tools for structure determination.
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