Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 18, Issue 3, Pages 358-365Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2008.02.006
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Current classification systems for protein structure show many inconsistencies both within and between systems. The metafold concept was introduced to identify fold similarities by consensus and thus provide a more unified view of fold space. Using cradle-loop barrels as an example, we propose to use the metafold as the next hierarchical level above the fold, encompassing a group of topologically related folds for which a homologous relationship has been substantiated. We see this as an important step on the way to a classification of proteins by natural descent.
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