Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 18, Issue 1, Pages 43-51Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2007.12.014
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Funding
- NIGMS NIH HHS [R01 GM063004-06A1, R01 GM063004] Funding Source: Medline
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ATP-dependent proteases control diverse cellular processes by degrading specific regulatory proteins. Recent work has shown that protein substrates are specifically transferred to ATP-dependent proteases through different routes. These routes can function in parallel or independently. In all of these targeting mechanisms, it can be useful to separate two steps: substrate binding to the protease and initiation of degradation.
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