Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 18, Issue 4, Pages 420-424Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2008.04.006
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- Swedish Research Council
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Protein complexes are a fundamental aspect of life in a membrane. It is therefore important to understand which proteins are assembled, and how the process of assembly is coordinated. To this end, a number of themes have emerged from the literature in recent years: first, membrane proteins assemble in an ordered, rather than a stochastic manner; second, they require chaperones to prevent unwanted interactions/aggregation; and third, they can be assembled into existing complexes. As these recurrent themes have emerged from studies on disparate complexes, they provide a general framework to understand the assembly of membrane proteins.
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