Journal
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
Volume 16, Issue 6, Pages 310-322Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cossms.2013.01.003
Keywords
siRNA delivery; Dendritic carrier; Lipid based carrier; Polyplex; Lipoplex
Funding
- German Ministry of Science (BMBF)
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RNA-based therapeutics has emerged as a novel and powerful approach for targeting a broad range of human diseases. Currently, a number of RNA-based drugs are under clinical investigation. The development of such drugs, however, has been slow and encountered multiple challenges. The clinical progress of such therapeutics strongly depends on whether a delivery vehicle efficiently and safely directs the drug into the target cells. Among the variety of non-viral vectors, dendritic carriers are particularly attractive due to their unique molecular architectures, globular shape, and multivalent groups on their surface. Lipid-based vectors were among the earliest strategies used for gene transfection and they are the most studied carriers for siRNA delivery. However, so far only a few of such systems have been studied in vivo. This review focuses on the most widely studied dendritic as well as lipid-based carriers for gene/siRNA delivery. (C) 2013 Elsevier Ltd. All rights reserved.
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