Journal
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
Volume 15, Issue 6, Pages 225-235Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cossms.2011.08.001
Keywords
Peptide amphiphiles; Self-assembly; Bioactive materials; Regenerative medicine; Bone regeneration; Enamel regeneration; Cartilage regeneration; Angiogenesis; Islet transplantation; Bioactive membranes
Funding
- National Institutes of Health [2R01DE015920-06, 2R01EB003806-06A2, 1U54CA151880-01]
- Department of Energy [DE-FG02-00ER45810]
- DARPA
- National Science Foundation
- Baxter Early Career Award in Bioengineering
- U.S. Department of Energy (DOE) [DE-FG02-00ER45810] Funding Source: U.S. Department of Energy (DOE)
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Self-assembling, peptide-based scaffolds are frontrunners in the search for biomaterials with widespread impact in regenerative medicine. The inherent biocompatibility and cell signaling capabilities of peptides, in combination with control of secondary structure, has led to the development of a broad range of functional materials with potential for many novel therapies. More recently, membranes formed through complexation of peptide nanostructures with natural biopolymers have led to the development of hierarchically-structured constructs with potentially far-reaching applications in biology and medicine. In this review, we highlight recent advances in peptide-based gels and membranes, including work from our group and others. Specifically, we discuss the application of peptide-based materials in the regeneration of bone and enamel, cartilage, and the central nervous system, as well as the transplantation of islets, wound-healing, cardiovascular therapies, and treatment of erectile dysfunction after prostatectomy. (C) 2011 Elsevier Ltd. All rights reserved.
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