Journal
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
Volume 15, Issue 6, Pages 277-284Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cossms.2011.06.003
Keywords
Polymersome; Drug delivery; Block copolymers; Nanoparticles; Paclitaxel; Phase separation
Funding
- NSF-MRSEC
- NSF-NSEC
- NIH
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1120901] Funding Source: National Science Foundation
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Polymer micelles and vesicles form upon hydration of amphiphilic block copolymers in dilute aqueous solution. Present challenges with these self-assemblies include understanding how molecular structure and polydispersity determine nano- and mesoscopic shape and properties such as flexibility. With charged copolymers, divalent ionic ligands can rigidify polymer vesicle membranes and also induce microphase separation into domains of weak polyelectrolyte gels. In this review, we focus on the underlying physical and molecular questions concerning copolymer assembly and associated challenges and implications for nano-delivery materials. We also highlight molecular simulation techniques that can be used to investigate properties of assemblies, such as curvature, patterning, and other ionic effects in functional polymeric membranes and micelles. (C) 2011 Elsevier Ltd. All rights reserved.
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