Journal
CURRENT OPINION IN RHEUMATOLOGY
Volume 23, Issue 5, Pages 459-464Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BOR.0b013e328349fd30
Keywords
activation of type I interferon pathway; Sjogren's syndrome; systemic lupus erythematosus
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Funding
- S. Niarchos Foundation
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Purpose of review Recent advances suggest type I interferon (IFN) pathway as an emerging mediator of systemic autoimmunity. This review aims to summarize the latest developments in the biology of type I IFN pathway and its contributory role in the pathogenesis of autoimmune disorders with a particular focus on Sjogren's syndrome. Recent findings Increased circulating type I IFN levels along with upregulated type I IFN inducible genes in salivary gland tissues, peripheral blood and mononuclear cells suggest activation of type I IFN pathway in Sjogren's syndrome. Additional regulatory mechanisms and novel potential suppressors of type I IFN production provide new insights into disease pathogenesis, pointing to type I IFN system as a potential new therapeutic target. Summary Compelling evidence suggests type I IFN as a key player in pathogenesis of Sjogren's syndrome and an attractive potential therapeutic target. Meticulous stratification of patient subgroups characterized by activation of type I IFN pathway should be performed in carefully designed translational studies.
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