Journal
CURRENT OPINION IN PULMONARY MEDICINE
Volume 18, Issue 1, Pages 14-22Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCP.0b013e32834dccc0
Keywords
asthma; elderly; eosinophil; microbe; microbiota
Categories
Funding
- NIH [1RO1CA152005-01, 1P30HL101265-0]
- VA Merit review
- Department of Veteran Affairs
Ask authors/readers for more resources
Purpose of review In this review, we describe the 'state-of-the-art' in our knowledge of asthma and what gaps exist, which can be exploited in the future for effective translation of our knowledge from the bench or population studies to diagnosis and therapy. Recent findings The advent of microbiome research has expanded the potential role of microbes in asthma. There has been a significant increase in our understanding of the pathologic, genetic, cellular and molecular mechanisms of asthma. Nonetheless, the contribution of microbes to the genesis, exacerbation and treatment of asthma are poorly understood. Summary Asthma is a complex chronic disease of the lung whose incidence is growing at all ages despite the progress that has been made in the areas of diagnosis and treatment of asthma. The complexity is partly due to the environmental insults such as allergens and microbial infections that play differential roles in the pathogenesis of childhood vis-a vis elderly asthma. Microbes may play important roles in the exacerbation of asthma and hence in the comorbidities due to asthma, and also in the causation of asthma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available