Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 93, Issue 7, Pages 1079-1092Publisher
WILEY
DOI: 10.1002/jnr.23583
Keywords
retina; Muller cell; glia; neuron; glucose; lactate shuttle; photoreceptor; astrocyte neuronal lactate shuttle
Categories
Funding
- NEI NIH HHS [R01 EY017863, R01 EY006641, R21 EY023346] Funding Source: Medline
- NIDDK NIH HHS [P30 DK017047] Funding Source: Medline
Ask authors/readers for more resources
The vertebrate retina has specific functions and structures that give it a unique set of constraints on the way in which it can produce and use metabolic energy. The retina's response to illumination influences its energy requirements, and the retina's laminated structure influences the extent to which neurons and glia can access metabolic fuels. There are fundamental differences between energy metabolism in retina and that in brain. The retina relies on aerobic glycolysis much more than the brain does, and morphological differences between retina and brain limit the types of metabolic relationships that are possible between neurons and glia. This Mini-Review summarizes the unique metabolic features of the retina with a focus on the role of lactate shuttling. (c) 2015 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available