Journal
CURRENT OPINION IN PLANT BIOLOGY
Volume 46, Issue -, Pages 96-103Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2018.08.003
Keywords
-
Categories
Funding
- National Science Foundation [MCB 1515220]
- National Institutes of Health [R01GM126557]
Ask authors/readers for more resources
The unicellular green alga Chlamydomonas provides a simplified model for defining core cell cycle functions conserved in the green lineage and for understanding multiple fission, a common cell cycle variation found in many algae. Systems-level approaches including a recent groundbreaking screen for conditional lethal cell cycle mutants and genome-wide transcriptome analyses are revealing the complex relationships among cell cycle regulators and helping define roles for CDKA/CDK1 and CDKB, the latter of which is unique to the green lineage and plays a central role in mitotic regulation. Genetic screens and quantitative single-cell analyses have provided insight into cell-size control during multiple fission including the identification of a candidate 'sizer' protein. Quantitative single-cell tracking and modeling are promising approaches for gaining additional insight into regulation of cellular and subcellular scaling during the Chlamydomonas cell cycle.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available