Journal
CURRENT OPINION IN PLANT BIOLOGY
Volume 13, Issue 5, Pages 578-586Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2010.09.005
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Funding
- National Institute of Health [GM56265, GM074813]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM056265, R29GM056265, R01GM074813] Funding Source: NIH RePORTER
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The initial photochemistry of plant cryptochromes has been extensively investigated in recent years. It is hypothesized that cryptochrome photoexcitation involves a Trp-triad-dependent photoreduction. According to this hypothesis, cryptochromes in the resting state contain oxidized FAD; light triggers a sequential electron transfer from three tryptophan residues to reduce FAD to a neutral semiquinone (FADW(center dot)); FADH(center dot) is the presumed signaling state and it is re-oxidized to complete the photocycle. However, this photoreduction hypothesis is currently under debate. An alternative model argues that the initial photochemistry of cryptochromes involves a photolyaselike cyclic electron shuttle without a bona fide redox reaction mediated by the Trp-triad residues, leading to conformational changes, signal propagation, and physiological responses.
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