Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 43, Issue -, Pages 66-71Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2018.08.011
Keywords
-
Categories
Funding
- Swedish Research Council (VR-Medicine and Health) [2017-02475]
- Swedish Research Council [2017-02475] Funding Source: Swedish Research Council
Ask authors/readers for more resources
The intestinal mucosa is constantly exposed to harmful lumina! content, and uptake is closely controlled and regulated by neuro-immune factors. If control is broken, it might lead to ongoing enhanced mucosal permeability, potentially resulting in functional gastrointestinal disorders. The importance of mast cells in the regulation of the mucosal barrier has become obvious, and increased numbers and more activated mast cells have been observed in irritable bowel syndrome, functional dyspepsia and gastroesophageal reflux disease. To target the disturbed mucosal permeability, directly or via mast cells, is therefore currently of major interest. For example, administration of mast cell stabilizers and probiotics have shown promising effects in patients with functional gastrointestinal disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available