Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 17, Issue -, Pages 45-57Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2014.07.002
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Funding
- M.I.U.R. (Rome, Italy)
- Regione Campania CISI-Lab
- CReME
- TIMING
- Paul Ehrilch Award
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Mast cells produce a wide spectrum of mediators and they have been implicated in several physiopathological conditions (e.g. allergic reactions and certain tumors). Pharmacologic agents that modulate the release of mediators from mast cells has helped to elucidate the biochemical mechanisms by which immunological and non-immunological stimuli activate these cells. Furthermore, the study of surface receptors and signaling pathways associated with mast cell activation revealed novel pharmacologic targets. Thus, the development of pharmacologic agents based on this new wave of knowledge holds promise for the treatment of several mast cell-mediated disorders.
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