Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 11, Issue 1, Pages 23-28Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2011.01.006
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Funding
- American Heart Association [0660032Z]
- National Institutes of Health National Heart Lung and Blood Institute [R01 HL091196, R01 HL091196-01A2W1]
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Advances over the past decade have improved our understanding of the serotonin (5-HT) biology outside the central nervous system specifically the molecular mechanisms of serotonergic signaling in association with small GTPases. It is now recognized that the communication between 5-HT and GTPases plays important roles in peripheral tissues, vascular cells and are involved in coagulation, hypertension, inflammation, healing and protection. Furthermore, 5-HT receptors as heterotrimeric GTP-binding protein-coupled receptors act as effector protein on the small GTPases. Therefore, the antagonists or agonists of the effector proteins of small GTPases could be useful therapeutic agents for the treatment of several diseases and disorders.
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