Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 10, Issue 6, Pages 770-774Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2010.09.001
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Funding
- NIH [GM31749]
- NSF [MCB 0506593, MCA93S013]
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Protein flexibility plays a critical role in ligand binding to both orthosteric and allosteric sites We here review some of the computer-aided drug-design techniques currently used to account for protein flexibility, ranging from methods that probe local receptor flexibility in the region of the protein immediately adjacent to the binding site, to those that account for general flexibility in all protein regions
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