Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 10, Issue 1, Pages 23-29Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2009.09.010
Keywords
-
Categories
Funding
- Medical Research Council U.K. [G0900050]
- Biotechnology and Biological Sciences Research Council [BB/E006302/1]
- BBSRC [BB/E006302/1] Funding Source: UKRI
- MRC [G9811527, G0900050] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E006302/1] Funding Source: researchfish
- Medical Research Council [G0900050, G9811527] Funding Source: researchfish
Ask authors/readers for more resources
The concept that G-protein-coupled receptors can exist as homomeric and/or heteromeric complexes is now well established. Despite this, how dynamic such interactions are and if this may be modulated during receptor trafficking remain topics of debate. Use of endoplasmic reticulum trapping strategies and the generation of asymmetric homomers have started to provide information on the contribution of protein-protein interactions to receptor maturation, cell surface delivery and ligand-mediated endocytosis. Although dimer/oligomer formation appears to be essential for cell surface delivery of class A and class C GPCRs, this may not be the case for class B receptors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available