Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 10, Issue 2, Pages 179-184Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2009.11.003
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Funding
- National Institutes of Health [HL8115, HL64937]
- Complexa, Inc.
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Vascular inflammatory disorders are often associated with both decreased NO bioavailability and a lack of responsiveness to NO, a consequence of impaired NO biosynthesis, dysregulated L-arginine metabolism, endothelial nitric oxide synthase (eNOS) uncoupling and NO consumption induced by redox reactions of NO. The latter is mediated via oxidative inflammatory conditions altering NO-dependent endothelial function, including vascular tone and cell proliferation. The redox reactions of NO and byproducts such as nitrite can react to yield electrophilic nitro-fatty acid derivatives (NO2-FAs) and exemplify a biochemical convergence of reactions participating in NO and lipid signaling. NO2-FAs represent a novel therapeutic strategy to treat vascular disorders by improving endothelial dysfunction through enhancing NO signaling and blocking vascular smooth muscle proliferation, inflammation, and maladaptive remodeling.
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