Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 9, Issue 1, Pages 74-80Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2008.12.016
Keywords
-
Categories
Funding
- National Institutes of Health-National Institute on Drug Abuse Research Center [P60-DA05130]
- National Institutes of Health-National Institute on Mental Health [MH-79880]
- National Center for Research Resources [UL1RR024143]
- New York State Office of Alcoholism and Substance Abuse Services [C003189]
Ask authors/readers for more resources
This review primarily focuses on our recent findings in bidirectional translational research on opiate and cocaine addictions. First, we present neurobiological and molecular studies on endogenous opioid systems (e.g. proopiomelanocortin, mu opioid receptor, dynorphin, and kappa opioid receptor), brain stress-responsive systems (e.g. orexin, arginine vasopressin, V1b receptor, and corticotropin-releasing factor), hypothalamic-pituitary-ad renal axis, and neurotransmitters (especially dopamine), in response to both chronic cocaine or opiate exposure and to drug withdrawal, using several newly developed animal models and molecular approaches. The second aspect is human molecular genetic association investigations including hypothesis-driven studies and genome-wide array studies, to define particular systems involved in vulnerability to develop specific addictions, and response to pharmacotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available