Journal
CURRENT OPINION IN PEDIATRICS
Volume 24, Issue 2, Pages 259-265Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOP.0b013e3283506765
Keywords
anticonvulsants; antipyretics; febrile seizure; laboratory evaluation; neurodiagnostic evaluation
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Purpose of review We summarize recent clinical reviews and updated American Academy of Pediatrics (AAP) clinical guidelines for the management of children with simple febrile seizures. Recent findings There has been a dramatic reduction in the incidence of bacterial meningitis and of occult bacteremia since the advent of Haemophilus influenzae type b and Streptococcus pneumoniae immunization. This has made routine laboratory evaluation for these bacterial infections unnecessary in a fully immunized, well appearing child who presents with a simple febrile seizure. At the same time there is increasing evidence that the neurotropic human herpes viruses 6 and 7 (HHV-6, HHV-7) comprise a significant proportion of viral infections associated with febrile seizures, and may be the primary cause of the seizure in many instances. Recent evidence-based guidelines emphasize the lack of a need for routine laboratory and neurodiagnostic evaluation, and for prophylactic antipyretics and anticonvulsants, in the majority of children with simple febrile seizures. Summary If a child who is fully immunized according to the recommended schedule presents with a simple febrile seizure, minimal intervention should be the norm. Routine blood tests and routine lumbar punctures are usually unnecessary, and the risks of neurodiagnostic procedures (imaging or EEG), prophylactic antipyretics and anticonvulsants far outweigh their potential benefits.
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