Journal
CURRENT OPINION IN PEDIATRICS
Volume 23, Issue 2, Pages 181-185Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOP.0b013e328342fe67
Keywords
acute kidney injury; continuous renal replacement therapy; fluid overload
Categories
Funding
- Gambro Renal Products
- Baxter Inc.
- Dialysis Solutions Incorporated
- B. Braun, Inc.
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Purpose of review Continuous renal replacement therapy (CRRT) is the most common dialysis modality provided to critically ill children with acute kidney injury (AKI). However, confusion still exists with respect to CRRT terminology and the optimal use of this modality across the entire pediatric disease and age spectrum. Recent findings Data from both single-center and multicenter pediatric studies demonstrate that CRRT can be provided effectively to all pediatric patients, from infants to young adult aged patients. Furthermore, these data demonstrate a consistent and independent association between the degree of patient fluid accumulation at the initiation of a CRRT course and mortality in critically ill children with AKI. In addition, CRRT has been successfully utilized for rapid clearance of both exogenous and endogenous (e.g., ammonia) toxins without the concentration rebound that characterizes toxin removal by intermittent hemodialysis. Summary CRRT represents an essential dialytic modality for the pediatric nephrologist caring for critically ill children. Current data suggest that earlier initiation of CRRT to prevent excessive fluid accumulation may lead to improved survival in critically ill children, but prospective trials are required to test this hypothesis directly.
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