Journal
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
Volume 22, Issue 2, Pages 81-89Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOO.0000000000000038
Keywords
anatomy; depth of infiltration; floor of mouth; oral cancer; oral tongue; TNM; tumor thickness
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Purpose of reviewTo summarize recent acquisitions in three-dimensional tongue and floor of mouth anatomy that can help in better evaluation of the pathways of cancer progression within these oral subsites, thus giving some hints for refining of the current TNM staging system.Recent findingsThe Visual Human Project is an initiative aimed at establishing a three-dimensional dataset of anatomy of two cadavers made available free to the scientific community. Visual human data have been analyzed by specific software thus improving our three-dimensional understanding of the tongue myostructure. It is already known that there is limited prognostic utility in using the two-dimensional surface diameter alone as criterion for T1-T3 definition. Recently, also the T4a categorization for the infiltration of deep' or extrinsic tongue muscles has been criticized. This is largely because the descriptor deep' does not take into account the fact that considerable portions of these muscles lie in a very superficial plane. Different prognosticators have been proposed for inclusion into the TNM staging system of oral cancer but depth of tumor infiltration' seems to be the most robust, universally recognized, and reproducible in the preoperative, intraoperative, and postoperative settings.SummaryOral tongue and floor of mouth cancer needs to be classified according to a revised TNM staging system in which depth of infiltration' should be taken into account. An ideal cut off' for distinguishing low' (T1-T2) from high-risk' (T3-T4) categories has been proposed based on the literature review, but needs retrospective as well as large prospective trials before its validation.
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