Journal
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
Volume 20, Issue 4, Pages 246-253Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOO.0b013e328355580e
Keywords
allograft; autograft; composite grafts; immunosuppression; prefabrication; prosthetic; scaffold; tissue engineering; tracheal reconstruction; tracheal stenosis
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Purpose of review Many patients require tracheal reconstruction either for tracheal stenosis/malacia or following tumor extirpation. However, such patients can be debilitated following failed conventional treatments. Recent advances in tissue engineering and vascularized composite grafts are accelerating the field of tracheal reconstruction. This article reviews new clinical concepts for tracheal reconstruction. Recent findings Novel treatments include composite autografts, allografts, chimeric autografts and allografts, tissue-engineered grafts, prosthetic scaffolds, and the use of free-tissue vascularized carriers. Summary New procedures for tracheal reconstruction hold much promise for treating difficult tracheal disorders and improving the quality of life for affected patients. Many of the techniques reviewed herein are single case series and require further investigation and validation.
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