Journal
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
Volume 18, Issue 5, Pages 454-458Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOO.0b013e32833e05ec
Keywords
antibiotics; cochlea; hair cell; hearing; otoprotection; vestibular
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Funding
- National Institute of Deafness and other Communication Disorders (NIDCD)/National Institutes of Health (NIH) [R01DC006283]
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Purpose of review To summarize advances in the study of the interaction between sensory hair cells and aminoglycoside antibiotics. Recent findings Aminoglycosides enter hair cells through mechanotransduction channels and initiate an active signaling pathway that leads to cell death. Early expression of heat shock proteins can protect hair cells from aminoglycosides, although signaling from surrounding supporting cells appears to promote hair cell death. Studies of certain human deafness mutations have revealed new insights into the role of mitochondria in aminoglycoside ototoxicity. Summary The cellular mechanisms of aminoglycoside ototoxicity continue to be an active topic of research and newly developed animal models offer great promise for future advances. Nevertheless, proven clinical methods for the prevention of ototoxic injury are not yet available.
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