Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 242, Issue -, Pages 52-57Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2014.12.018
Keywords
Magnetic resonance spectroscopy; Transcranial magnetic stimulation; Co-registration; Co-visualization
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Funding
- aQuebec Bioimaging Network travel award
- CIRRIS scholarship
- NSERC
- NIH [R01 NS075184, P41 EB015909, R01 EB016089]
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Transcranial magnetic stimulation (TMS) is a widely used tool for noninvasive modulation of brain activity, that is thought to interact primarily with excitatory and inhibitory neurotransmitter systems. Neurotransmitters such as glutamate and GABA can be measured by magnetic resonance spectroscopy (MRS). An important prerequisite for studying the relationship between MRS neurotransmitter levels and responses to TMS is that both modalities should examine the same regions of brain tissue. However, co-registration of TMS and MRS has been little studied to date. This study reports on a procedure for the co-registration and co-visualization of MRS and TMS, successfully localizing the hand motor cortex, as subsequently determined by its functional identification using TMS. Sixteen healthy subjects took part in the study; in 14 of 16 subjects, the TMS determined location of motor activity intersected the (2.5 cm)(3) voxel selected for MRS, centered on the so called 'hand knob' of the precentral gyrus. It is concluded that MRS voxels placed according to established anatomical landmarks in most cases agree well with functional determination of the motor cortex by TMS. Reasons for discrepancies are discussed. (C) 2015 Elsevier B.V. All rights reserved.
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