Journal
CURRENT OPINION IN ORGAN TRANSPLANTATION
Volume 14, Issue 4, Pages 403-409Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOT.0b013e32832ca2b8
Keywords
antigenicity; HLAMatchmaker; human leukocyte antigen antibody; human leukocyte antigen epitope; immunogenicity
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Funding
- National Institutes of Health [RO1-AI-55933]
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Purpose of review This review addresses the concept that human leukocyte antigen (HLA) antibody specificity should be determined to HLA epitopes rather than HLA antigens. Recent findings HLAMatchmaker is a computer algorithm that considers small configurations of polymorphic residues referred to as eplets as essential components of HLA epitopes. This overview describes recent developments that have increased our understanding of structural epitope antigenicity, that is, reactivity with specific antibody and immunogenicity, that is, its ability to induce an antibody response. Summary A determination of the repertoire of immunogenic epitopes is important for HLA compatibility testing and the identification of acceptable mismatches for sensitized patients.
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