Journal
JOURNAL OF NEUROSCIENCE
Volume 35, Issue 46, Pages 15419-15429Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1449-15.2015
Keywords
alpha-melanocyte-stimulating hormone; arcuate; median preoptic nucleus; suprachiasmatic; body temperature; vasopressin
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Funding
- Direccion General Asuntos del Personal Academico [GAPA IG-200314]
- Consejo Nacional de Ciencia y Tecnologia [CONACyT 220598]
- CONACyT doctoral student grant
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In mammals, daily changes in body temperature (Tb) depend on the integrity of the suprachiasmatic nucleus (SCN). Fasting influences the Tb in the resting period and the presence of the SCN is essential for this process. However, the origin of this circadian/metabolic influence is unknown. We hypothesized that, not only the SCN but also the arcuate nucleus (ARC), are involved in the Tb setting through afferents to the thermoregulatory median preoptic nucleus (MnPO). Therefore, we investigated by neuronal tracing and microdialysis experiments the possible targeting of the MnPO by the SCN and the ARC in male Wistar rats. We observed that vasopressin release from the SCN decreases the temperature just before light onset, whereas alpha-melanocyte stimulating hormone release, especially at the end of the dark period, maintains high temperature. Both peptides have opposite effects on the brown adipose tissue activity through thermoregulatory nuclei such as the dorsomedial nucleus of the hypothalamus and the dorsal raphe nucleus. The present study indicates that the coordination between circadian and metabolic signaling within the hypothalamus is essential for an adequate temperature control.
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