Journal
JOURNAL OF NEUROSCIENCE
Volume 35, Issue 44, Pages 14740-14755Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1101-15.2015
Keywords
amblyopia; contrast sensitivity; cortex; fMRI; pRF mapping; retinotopy
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Funding
- two Canadian Institutes of Health Research grants [MOP-53346, MOP-10818]
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The neural basis of amblyopia is a matter of debate. The following possibilities have been suggested: loss of foveal cells, reduced cortical magnification, loss of spatial resolution of foveal cells, and topographical disarray in the cellular map. To resolve this we undertook a population receptive field (pRF) functional magnetic resonance imaging analysis in the central field in humans with moderate-to-severe amblyopia. We measured the relationship between averaged pRF size and retinal eccentricity in retinotopic visual areas. Results showed that cortical magnification is normal in the foveal field of strabismic amblyopes. However, the pRF sizes are enlarged for the amblyopic eye. We speculate that the pRF enlargement reflects loss of cellular resolution or an increased cellular positional disarray within the representation of the amblyopic eye.
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