Local injury to the endometrium: its effect on implantation

Purpose of review TO review the effect of local injury to the endometrium on the implantation rate in IVF-embryo transfer. Recent findings In 2003, Barash et al. reported that endometrial sampling of IVF patients using a biopsy catheter substantially increases their chances to conceive at the following IVF-embryo transfer cycle. Such a favorable influence of local injury to the endometrium was later confirmed by Raziel et al. Our previous studies demonstrated that removal of ploys or thickening endometrium 2 weeks before embryo transfer significantly improves the incidence of successful pregnancies in patients undergoing IVF. In 2008, our study suggested that the gene-expression profile of endometria from patients with different pregnancy results are different. Summary Local injury to endometria of IVF patients in controlled ovarian hyperstimulation cycle may increase the incidence of embryo implantation.