Journal
CURRENT OPINION IN NEUROLOGY
Volume 26, Issue 6, Pages 662-670Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WCO.0000000000000034
Keywords
coherence; electroencephalography; local field potentials; magnetoencephalography; spectral analysis; subthalamic nucleus
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Funding
- Medical Research Council
- Wellcome Trust
- Rosetrees Trust
- National Institute of Health Oxford Biomedical Research Centre
- Medical Research Council [G0901503] Funding Source: researchfish
- MRC [G0901503] Funding Source: UKRI
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Purpose of the review Developments in functional neurosurgery for movement disorders and recent advances in electrophysiological techniques have allowed important insights into the role of oscillations in corticobasal ganglia circuits, both in health and in neurological disease states. Here we review recent developments in our understanding of how abnormally synchronized oscillatory activity within the corticobasal ganglia loop may play a key role in the pathophysiology of cognitive and motor phenotypes in Parkinson's disease. Recent findings Recent developments highlight the motor and non-motor roles of , and oscillations in the context of Parkinson's disease. They also emphasize the importance of oscillatory coupling between basal ganglia and cortex and draw attention to the importance of interactions between different frequency bands. Summary Oscillatory activities across multiple frequency bands and their cross-frequency interactions within spatially segregated loops of the basal ganglia-thalamo-cortical system may relate to distinct components of clinical impairment, both motor and non-motor. It is hoped that this characterization will lead to improved interventions like deep brain stimulation, tailored to specific components of clinical impairment and their associated spatial and spectral signatures.
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