Journal
CURRENT OPINION IN NEUROLOGY
Volume 23, Issue 3, Pages 266-274Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WCO.0b013e32833821c1
Keywords
artery; constriction; cortical spreading depression; dilation; migraine; trigeminovascular
Categories
Funding
- National Institutes of Health [K08 NS059072]
- Larry L. Hillblom Foundation
- Migraine Research Foundation
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Purpose of review The cranial blood vessel is considered an integral player in the pathophysiology of migraine, but its perceived role has been subject to much discussion and controversy over the years. We will discuss the evolution in our scientific understanding of cranial blood vessels (primarily arteries) in migraine. Recent findings Recent developments have clarified the role of cranial blood vessels in the trigeminovascular system and in cortical spreading depression. An underlying theme is the intimate relation between vascular activity and neural function, and we will emphasize the various roles of the blood vessel that go beyond delivering blood. We conclude that migraine cannot be understood, either from a research or clinical point of view, without an understanding of the vascular derangements that accompany it. Summary Migraine is accompanied by significant derangements in vascular function that may represent important targets for investigation and treatment.
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