Improving the role of intraventricular antimicrobial agents in the management of meningitis

Purpose of review The aim is to review the role of intraventricular administration of antimicrobial agents in the treatment of patients with bacterial and fungal meningitis. Recent findings This article discusses indications for intraventricular antimicrobial agents, choice of antibiotics, strategies to monitor pharmacokinetics of central nervous system compartments and unanswered issues for this management approach. Summary Intraventricular administration of antimicrobials may be necessary in certain difficult-to-eradicate central nervous system infections. There is a significant need for clinical trials and management guidelines in this area.