Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 53, Issue -, Pages 110-119Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2018.07.002
Keywords
-
Categories
Funding
- National Institute of Health [R01NS069844]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS069844] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Signaling through the dual leucine zipper-bearing kinase (DLK) is required for injured neurons to initiate new axonal growth; however, activation of this kinase also leads to neuronal degeneration and death in multiple models of injury and neurodegenerative diseases. This has spurred current consideration of DLK as a candidate therapeutic target, and raises a vital question: in what context is DLK a friend or foe to neurons? Here, we review our current understanding of DLK's function and mechanisms in regulating both regenerative and degenerative responses to axonal damage and stress in the nervous system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available