Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 53, Issue -, Pages 131-138Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2018.07.006
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Funding
- Laboratory for Excellence Programme Revive
- Institut Pasteur
- Agence Nationale de la Recherche [ANR-15-CE37-0004-01]
- Laboratory for Excellence Programme Revive (Investissement d'Avenir) [ANR-I0-LABX-73]
- Centre National pour la Recherche Scicntifique
- life insurance company AG2R-La-Mondiale
- Biopsy (Investissement d'Avenir) [ANR-11-IDEX-0004-02]
- NIH US-Frcnch Research Proposal Grants [1R01DC015137-01, ANR-15-NEUC-0004]
- Agence Nationale de la Recherche (ANR) [ANR-15-NEUC-0004, ANR-15-CE37-0004] Funding Source: Agence Nationale de la Recherche (ANR)
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Neural stem cells (NSCs) represent a remarkable developmental unit, necessary for the proper functioning of neurogenesis, by retaining their plasticity to self-renew and give rise to progeny throughout life in specific regions of the adult brain. Although NSCs were thought to merely represent a stem cell type in the brain, recent advances have demonstrated the incredible complexity of NSC identity and functions. Ranging between quiescence, activation and intermediary subtypes, NSCs choose their fate through their developmental inheritance, regional positioning within the niche, as well as dynamic transcriptional and metabolic states. The plasticity of their developmental program is reflected in the tremendous changes they undergo upon external environmental cues and extrinsic manipulations, and harnessing these potentials can open new avenues to fight against brain injury, neurodegenerative and age-related diseases.
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