Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 29, Issue -, Pages 25-32Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2014.04.010
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Funding
- NIH [NS26464, MH46613]
- Tartar Trust
- ARCS
- National Science Foundation [DGE0925180]
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Co-transmission, the ability of a neuron to release multiple transmitters, has long been recognized in selected circuits. However, the release of multiple primary neurotransmitters from a single neuron is only beginning to be appreciated. Here we consider recent examples of co-transmission as well as co-release the packaging of multiple neurotransmitters into a single vesicle. The properties associated with each mode of release greatly enhance the possible action of such neurons within circuits. The functional importance of dual-(or multi-) transmitter neurons extends beyond actions on postsynaptic receptors, due in part to differential spatial and temporal profiles of each neurotransmitter. Recent evidence also suggests that the dual-transmitter phenotype can be dynamically regulated during development and following injury or disease.
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