Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 23, Issue 1, Pages 119-126Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2012.11.001
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Funding
- CNRS
- Inserm
- Fondation Bettencourt Schueller
- Fondation Institut du Cerveau et de la Moelle epiniere (ICM)
- Emergence from the Maine de Paris
- NERF region
- FYSSEN foundation
- International Reintegration Grant (IRG) from the Marie Curie Action
- European Research Council
- Howard Hughes Medical Institute
- Wellcome Trust
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Optogenetic tools can be used to manipulate neuronal activity in a reversible and specific manner. In recent years, such methods have been applied to uncover causal relationships between activity in specified neuronal circuits and behavior in the larval zebrafish. In this small, transparent, genetic model organism, noninvasive manipulation and monitoring of neuronal activity with light is possible throughout the nervous system. Here we review recent work in which these new tools have been applied to zebrafish, and discuss some of the existing challenges of these approaches.
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