Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 22, Issue 6, Pages 1054-1061Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2012.06.004
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Funding
- National Science Foundation
- National Institute of Mental Health [R01-MH079292]
- National Institute on Drug Abuse [R01-DA027858]
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Environmental stimuli guide value-based decision making, but can do so through cognitive representation of outcomes or through general-incentive properties attributed to the cues themselves. We assert that these differences are conferred through the use of alternative associative structures differing in computational intensity. Using this framework, we review scientific evidence to discern the neural substrates of these assumed separable processes. We suggest that the contribution of the mesolimbic dopamine system to Pavlovian valuation is restricted to an affective system that is only updated through experiential feedback of stimulus-outcome pairing, whereas the orbitofrontal cortex contributes to an alternative system capable of inferential reasoning. Finally we discuss the interactions and convergence of these systems and their implications for decision making and its pathology.
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