Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 22, Issue 3, Pages 470-479Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2011.09.008
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Funding
- NIH Pathway to Independence Award from NIMH [K99 MH090239-01A1]
- NINDS Intramural Research Program
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In the mammalian central nervous system, the majority of fast excitatory synaptic transmission is mediated by glutamate acting on AMPA-type ionotropic glutamate receptors. The abundance of AMPA receptors at the synapse can be modulated through receptor trafficking, which dynamically regulates many fundamental brain functions, including learning and memory. Reversible posttranslational modifications, including phosphorylation, palmitoylation and ubiquitination of AMPA receptor subunits are important regulatory mechanisms for controlling synaptic AMPA receptor expression and function. In this review, we highlight recent advances in the study of AMPA receptor posttranslational modifications and discuss how these modifications regulate AMPA receptor trafficking and function at synapses.
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