Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 22, Issue 5, Pages 822-828Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2012.03.012
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Funding
- Italian Ministry of Health
- Italian Ministry of University and Research (PRIN grant)
- Italian Space Agency (DCMC grant)
- European Union FP7-ICT [248311]
- Italian Space Agency (CRUSOE grant)
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Neural control of locomotion in human adults involves the generation of a small set of basic patterned commands directed to the leg muscles. The commands are generated sequentially in time during each step by neural networks located in the spinal cord, called Central Pattern Generators. This review outlines recent advances in understanding how motor commands are expressed at different stages of human development. Similar commands are found in several other vertebrates, indicating that locomotion development follows common principles of organization of the control networks. Movements show a high degree of flexibility at all stages of development, which is instrumental for learning and exploration of variable interactions with the environment.
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