Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 21, Issue 1, Pages 132-143Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2010.08.016
Keywords
-
Categories
Funding
- Michael Smith Foundation for Health Research
- Canada Research Chair
- Canadian Institutes of Health Research [MOP-84241]
- National Institutes of Health [R01-MH070860]
- Mind Foundation of British Columbia
Ask authors/readers for more resources
A number of synaptogenic factors induce presynaptic or postsynaptic differentiation when presented to axons or dendrites. Many such factors participate in bidirectional trans-synaptic adhesion complexes. Axonal neurexins interacting in an isoform-specific code with multiple dendritic partners (neuroligins, LRRTMs, or Cbln-GluR delta), and axonal protein tyrosine phosphatase receptors interacting with dendritic NGL-3, nucleate local networks of high-affinity protein-protein interactions leading to aligned presynaptic and postsynaptic differentiation. Additional secreted target-derived factors such as fibroblast growth factors and glial-derived factors such as thrombospondin bind specific axonal or dendritic receptors stimulating signal transduction mechanisms to promote selective aspects of synapse development. Together with classical adhesion molecules and controlled by transcriptional cascades, these synaptogenic adhesion complexes and secreted factors organize the molecular composition and thus functional properties of central synapses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available