Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 21, Issue 2, Pages 299-305Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2011.01.002
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Funding
- Medical Research Council
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council
- EMBO
- MRC [G0902044] Funding Source: UKRI
- Medical Research Council [G0902044] Funding Source: researchfish
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According to the theory of neuronal health, neurons exist in a spectrum of states ranging from highly resilient to vulnerable. An unhealthy neuron may be rendered dysfunctional or nonviable by an insult that would ordinarily be non-toxic to a healthy neuron. Over the years it has become clear that a neuron's health is subject to dynamic regulation by electrical or synaptic activity. This review highlights recently identified activity dependent signalling events that boost neuronal health through the transcriptional control of pro-apoptotic and antiapoptotic genes, the enhancement of antioxidant defences, and the regulation of mitochondrial and neurotrophic factor availability. Furthermore, activity dependent signals have recently been shown to influence a variety of events specific to individual neurodegenerative diseases, which will also be highlighted.
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