Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 21, Issue 6, Pages 866-872Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2011.05.013
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Funding
- NIMH NIH HHS [R01 MH051234-16, P50 MH084053-05, R01 MH043784, R21 MH085108-02, R21 MH085108, R01 MH051234, R01 MH071533, P50 MH084053] Funding Source: Medline
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Deficits of cognitive control in schizophrenia are associated with altered gamma oscillations in the prefrontal cortex. Paralbumin basket interneurons, which innervate the perisomatic region of pyramidal neurons, appear to play a key role in generating cortical gamma oscillations. In the prefrontal cortex of subjects with schizophrenia, alterations are present in both pre- and post-synaptic markers of the strength of GABA inputs from parvalbumin basket neurons to pyramidal neurons. These alterations may contribute to the neural substrate for impaired gamma oscillations in schizophrenia.
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