Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 21, Issue 4, Pages 571-578Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2011.05.002
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Funding
- NIH-NINDS [R01 NS66408]
- McKnight Foundation
- Klingenstein Foundation
- Sloan Foundation
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How neural circuits underlie the acquisition and control of learned motor behaviors has traditionally been explored in monkeys and, more recently, songbirds. The development of genetic tools for functional circuit analysis in rodents, the availability of transgenic animals with well characterized phenotypes, and the relative ease with which rats and mice can be trained to perform various motor tasks, make rodents attractive models for exploring the neural circuit mechanisms underlying the acquisition and production of learned motor skills. Here we discuss the advantages and drawbacks of this approach, review recent trends and results, and outline possible strategies for wider adoption of rodents as a model system for complex motor learning.
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