Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 21, Issue 6, Pages 929-934Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2011.10.021
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Funding
- National Institute of Aging [P01-AG-09973]
- Ellison Medical Foundation
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This review is focused on specific circuits of the medial temporal lobe that have become better understood in recent years for their computational properties contributing to episodic memory and to memory impairment associated with aging and other risk for AD. The layer II neurons in the entorhinal cortex and their targets in the dentate gyrus and CA3 region of hippocampus comprise a system that rapidly encodes representations that are distinct from prior memories. Frank neuron loss in the entorhinal cortex is specific for AD, and related structural and functional changes across the network comprised of the entorhinal cortex and the dentate/CA3 regions hold promise for predicting progression on the path to AD.
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