Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 20, Issue 2, Pages 231-235Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2010.02.005
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH086400, R01MH058883, R01MH081975] Funding Source: NIH RePORTER
- NIMH NIH HHS [R01 MH058883, R01 MH081975, R01 MH058883-13, P50 MH086400-015561, P50 MH086400, R01 MH081975-02] Funding Source: Medline
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Although fear research has largely focused on the amygdala, recent findings highlight cortical control of the amygdala in the service of fear regulation. In rodent models, it is becoming well established that the infralimbic (IL) prefrontal cortex plays a key role in extinction learning, and recent findings are uncovering molecular mechanisms involved in extinction-related plasticity. Furthermore, mounting evidence implicates the prelimbic (PL) prefrontal cortex in the production of fear responses. Both IL and PL integrate inputs from the amygdala, as well as other structures to gate the expression of fear via projections to inhibitory or excitatory circuits within the amygdala. We suggest that dual control of the amygdala by separate prefrontal modules increases the flexibility of an organism's response to danger cues.
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