Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 20, Issue 5, Pages 617-622Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2010.08.018
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Funding
- Lucille P. Markey Stanford Graduate Fellowship
- NIH
- Simons Foundation
- Fidelity Foundation
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP1OD003889] Funding Source: NIH RePORTER
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Understanding the complexity of neuronal biology requires the manipulation of cellular processes with high specificity and spatio-temporal precision. The recent development of synthetic photo-activatable proteins designed using the light-oxygen-voltage and phytochrome domains provides a new set of tools for genetically targeted optical control of cell signaling. Their modular design, functional diversity, precisely controlled activity and in vivo applicability offer many advantages for investigating neuronal function. Although designing these proteins is still a considerable challenge, future advances in rational protein design and a deeper understanding of their photoactivation mechanisms will allow the development of the next generation of optogenetic techniques.
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