Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 20, Issue 5, Pages 557-562Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2010.06.002
Keywords
-
Categories
Funding
- NATIONAL EYE INSTITUTE [R01EY017656] Funding Source: NIH RePORTER
- NEI NIH HHS [R01 EY017656] Funding Source: Medline
Ask authors/readers for more resources
Recently, stable labeling techniques and use of two-photon microscopy for deep tissue imaging have enabled observation of neuronal structural dynamics within intact cerebral cortical circuits. These studies demonstrate that while neuronal structures are predominantly stable in the adult, a fraction of dendrites and axons are highly dynamic and responsive to experience, remodeling with precise cell type and laminar specificity. The qualitative and quantitative features of dendritic spine, dendritic branch, and axonal remodeling suggest that their purpose may be to provide access to and alter connectivity between different circuits in cortical space. The net number of synapses lost or gained during arbor remodeling may not be as important as the change to the circuit diagram resulting from the shuffling of synaptic partners.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available