Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 19, Issue 6, Pages 621-628Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2009.10.003
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Funding
- NS34696
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The striatum is thought to play a central role in learning how to choose acts that lead to reward and avoid punishment. Dopamine-dependent modification of striatal synapses in the action selection circuitry has long been thought to be a key step toward this type of learning. The development of new genetic and optical tools has pushed this field forward in the last couple of years, demanding a re-evaluation of models of how experience controls dopamine-dependent synaptic plasticity and how disease states like Parkinson's disease affect the striatal circuitry.
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