Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 19, Issue 3, Pages 237-244Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2009.06.006
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Funding
- Medical Research Council [G0700368] Funding Source: Medline
- MRC [G0700368] Funding Source: UKRI
- Medical Research Council [G0700368] Funding Source: researchfish
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Until recently we held the simple view that voltage-gated calcium channels consisted of an alpha 1 subunit, usually associated with auxiliary beta subunits and alpha 2 delta subunits and that skeletal muscle calcium channels were also associated with a gamma subunit. However, as discussed here, there is now evidence that the auxiliary subunits may also perform other roles unrelated to voltage-gated calcium entry. In the past students were taught the simplistic view that second messenger signaling to voltage-gated calcium channels involved mainly phosphorylation of L-type calcium channels, Ca2+-dependent inactivation via calmodulin, and direct G-protein-mediated inhibition of the neuronal N and P/Q channels. However, it is now clear that there are many other means of modulating calcium channel activity, including receptor-mediated internalization, proteolytic cleavage, phosphorylation of beta subunits, and interaction of calcium channels with other proteins, including enzymes masquerading as scaffold proteins.
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